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胃平片联合奥美拉唑胶囊治疗胃溃疡疗效观察
作者:蒋伟杰1 聂倩庆2 黄艳兰1 莫华澍1 
单位:1. 南方医科大学附属新会医院,广东 江门 529100;2. 江门市新会卫生中专学校,广东 江门 529100
关键词:胃平片 奥美拉唑 胃溃疡 
中图分类号:R969. 4
文献标志码:A
出版年,卷(期):页码:2011,21(5):295-296,
收稿日期:2010 - 12 - 17
摘要:
目的 观察胃平片联合奥美拉唑胶囊在治疗胃溃疡中的疗效。 方法 230 例胃溃疡患者随机分为 2 组,治疗组 120 例,给予胃平片(每次3 片,tid. )联合奥美拉唑胶囊(20 mg,qd. )治疗;对照组110 例,给予奥美拉唑胶囊(20 mg,qd. )治疗;2 组幽门螺杆菌阳性患者同时增加阿莫西林胶囊(1. 0 g,bid. ),克拉霉素片(0. 25 g,bid. ),治疗;疗程8 w。 结果 治疗组治愈率82. 5%,总有效率95. 0%,幽门螺杆菌阴转率85. 4%,1 y 复发率6. 7%;对照组分别为 61. 8%、85. 5%、80. 5%、15. 7%;2 组比较差异有统计学意义(P < 0. 05)。结论 胃平片联合奥美拉唑胶囊治疗胃溃疡,可有效减轻胃黏膜损伤,提高治疗质量,降低复发率。
Objective To observe the effect of Weiping tablets combined with the omeprazole capsule in the treatment of gastric ulcer. Methods A total of 230 patients with gastric ulcer were randomly divided into 2 groups. Patients in the treatment group (n =120) were treated with the Weiping tablets (3 tab. , tid. ) combined with omeprazole capsule (20 mg, qd. ). Patients in the control group ( n = 110) were only treated by omeprazole capsules (20 mg, qd. ). The ampicillin capsule (1. 0 g, bid. ) and clarithromycin (1.0 g, bid. ) were given to helicobacter pylori positive patients in those 2 groups. All the treatment was lasted for 8 w. Results The recovery rate, effective rate, total effective rate,helicobacter pylori negative rate, the relapse rate one year of patients in treatment group was 82. 5%, 95. 0%, 85. 4%,6. 7%, respectively; and patients in the control group was 61. 8%, 85. 5%, 80. 5%, 15. 7%, respectively. The difference between 2 groups was significant ( P < 0. 05). Conclusion Weiping tablets combined with omeprazole capsule in treatment of gastric ulcer is effective in reducing gastric mucosal injury, and can improve the treatment quality nd reduce the relapse rate.
基金项目:
江门市科技计划项目(编号:江科[2004]46 号,序号2)
作者简介:
蒋伟杰,副主任药师,Tel:0750 - 6197120,E-mail:jwj1962@126. com
通讯作者:
参考文献:
[1] 蒋伟杰,聂倩庆,陈小夏. 胃平分散片质量标准的研究[J]. 中国医药导报,2009,25(9):16 -18.
[2] 滕晓生. 奥美拉唑治疗幽门螺杆菌相关性胃溃疡的进展[J]. 中国临床医生,2005,33(8):41 -42.
[3] 中药新药临床研究指导原则[S]. 卫生部,1993:114 -117.
[4] 黄锦鸿,陈仁寿. 临床实用中药辞典[M]. 北京:金盾出版社,2005:510.
[5] 陈新谦,金有豫,汤光. 新编药物学[M]. 16 版,北京:人民卫生出版社,2007:483,459.
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