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卡前列素氨丁三醇与米索前列醇防治宫缩乏力性产后出血的效果比较
作者:杨虎 
单位:武汉科技大学附属天佑医院药剂科, 湖北 武汉 430064
关键词:卡前列素氨丁三醇 米索前列醇 宫缩乏力 产后出血 
中图分类号:R969.4
文献标志码:
出版年,卷(期):页码:2017,27(1):30-32,
收稿日期:2016-8-15
摘要:
目的 比较卡前列素氨丁三醇与米索前列醇防治宫缩乏力性产后出血的效果及不良反应。方法 70例宫缩乏力性产后出血高危因素的产妇根据数字表法随机分为2组,A组(n=35例)采用米索前列醇防治宫缩乏力性产后出血,B组(n=35例)采用卡前列素氨丁三醇防治宫缩乏力性产后出血。比较两组临床疗效、产后出血发生率、产后2 h和24 h出血量、第三产程时间、血红蛋白下降值及不良反应发生率。结果 B组治疗总有效率(94.29%)明显高于A组(77.14%)(P<0.05);B组产后2 h出血量、产后24 h出血量明显少于A组(P<0.05),第三产程时间明显快于A组(P<0.05),产后出血发生率和血红蛋白下降值明显高于A组(P<0.05);两组治疗期间均未出现严重不良反应,A组不良反应发生率(20.0%)与B组(14.29%)比较,差异无统计学意义(P>0.05)。结论 卡前列素氨丁三醇防治宫缩乏力性产后出血的效果优于米索前列醇,可明显降低产后出血率。
OBJECTIVE To compare the effect and adverse reaction of carboprost tromethamine and misoprostol for prevention of postpartum hemorrhage caused by uterine inertia. METHODS 70 cases with high risk factors of postpartum hemorrhage maternal were randomly divided into 2 groups, A group (n=35 cases) was used with misoprostol in prevention of postpartum hemorrhage caused by uterine inertia, B group (n=35 cases) was used with carboprost tromethamine. The clinical efficacy, the incidence of postpartum hemorrhage, the amount of 2 h and 24 h, the third labor time, the decrease of hemoglobin and the incidence of adverse reaction of two groups were compared. RESULTS The total effective rate of B group (94.29%) was significantly higher than that of A group(77.14%)(P<0.05). The 2 h postpartum hemorrhage, 24 h postpartum hemorrhage of B group was obviously less than that of A group(P<0.05), the third labor time was significantly faster than that of group A(P<0.05), and the incidence of postpartum hemorrhage and decrease in hemoglobin significantly higher than that of A group (P<0.05). There were no serious adverse reaction in two groups during the treatment, the incidence of adverse reactions in group A (20.0%) and B group (14.29%) showed no significant difference(P>0.05). CONCLUSION The effect of carboprost tromethamine for prevention of postpartum hemorrhage is better than misoprostol, can significantly reduce the rate of postpartum hemorrhage.
基金项目:
作者简介:
杨虎,主管药师,研究方向:医院药学,Tel:15927620517,E-mail:yanghuwhtyyy@126.com
通讯作者:
参考文献:
[1] Karoshi M, Keith L. Challenges in managing postpartum hemorrhage in resource-poor countries[J].Clin Obstet Gynecol,2009,52(2):285-298.
[2] 包智慧,龚晓华.卡前列素氨丁三醇与米索前列醇防治高危孕妇剖宫产术后产后出血的临床观察[J].实用药物与临床,2014,17(2):243-245.
[3] 付翔.难治性产后出血的高危因素分析及治疗研究[J].海南医学院学报,2013,19(2):235-238.
[4] 谭曼霞,倪莉.卡前列素氨丁三醇联合缩宫素在产后出血的应用价值[J].西部医学,2014,26(5):591-592.
[5] 汪新妮,彭幼,朱燕虹.预防性宫体注射卡前列素氨丁三醇在产后出血高危因素孕妇剖宫产术中的效果[J].广东医学,2012,33(5):696.
[6] 郑疆,陆莹.卡前列素氨丁三醇注射液和米索前列醇预防产后出血的临床对比分析[J].中国计划生育学杂志,2015,2(1):48-50.
[7] 乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2008:123-125.
[8] 乔宠,高嵩,刘彩霞,等.产时胎儿手术应用欣母沛预防母体产后出血的临床研究[J].实用药物与临床,2011,14(2):89-92.
[9] 高俊. 卡前列素氨丁三醇注射液(欣母沛)在子宫收缩乏力(剖宫产术)所致的产后出血中的应用[J].医药前沿,2014,41(9):214-215.
[10] 韦玉岚,潘春红.欣母沛联合钙剂预防高危产妇剖宫产术中产后出血疗效观察[J].右江民族医学院学报,2015,24(2):260-261.
[11] 申海健.卡前列素氨丁三醇与米索前列醇治疗产后出血的疗效观察[J].实用临床医药杂,2010,14(19):73-75.
[12] 李嘉蔚,刘周成,张江字,等.欣母沛预防产后出血30例临床观察[J].中国妇幼保健,2010,25(10):1451-1452.
[13] 刘水策.应用欣母沛预防前置胎盘产后出血的临床研究[J].实用药物与临床, 2010,13(1):25-26.
[14] 董美娟.欣母沛防治高危剖宫产孕妇产后出血的疗效观察[J].实用药物与临床, 2013,16(1):33-34.
[15] 董波.欣母沛治疗产后出血87例临床分析[J].中国妇幼保健,2011,26(11):1757-1758.
[16] 尚作美.米索前列醇联合催产素对剖宫产产后出血的预防作用[J].安徽医药,2013,17(2):307-308.
[17] 申健.卡前列素氨丁三醇对剖宫产术患者血钙、D-二聚体水平的影响及产后出血的防治效果[J].解放军医药杂志,2016,28(2):93-95.
[18] 计静,米阳,赵现立,等.不同时机宫体注射欣母沛预防剖宫产术中宫缩乏力产后出血的疗效观察[J].四川医学,2013,34(7):1047-1048.
[19] 谢丽珍,刘慧芳,刘咏芳.依沙吖啶配伍米索前列醇在引产术的临床观察[J].今日药学,2010,20(1):53-54.
[20] Eke AC, Shukr GH, Chaalan TT, et al. Intra-abdominal saline irrigation at cesarean section:a systematic review and meta-analysis[J]. J Matern Fetal Neonatal Med,2015,129(11):1-7.
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