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埃索美拉唑针剂治疗非静脉曲张性上消化道出血的疗效观察
作者:杨丽芳  李伟珍  林玉燕  龚荣达  吴红苗 
单位:茂名石化医院, 广东 茂名 525000
关键词:埃索美拉唑 奥美拉唑 非静脉曲张性上消化道出血 疗效 安全性 
中图分类号:R969.4
文献标志码:
出版年,卷(期):页码:2017,27(1):33-36,
收稿日期:2016-11-9
摘要:
目的 观察埃索美拉唑针剂对非静脉曲张性上消化道出血患者的止血效果与安全性。方法 将本院收治的138例非静脉曲张性上消化道出血患者,随机分为观察组(70例)和对照组(68例),两组均给予止血、补充血容量、维持生命体征的常规治疗,在此基础上观察组加用埃索美拉唑静脉滴注,对照组加用奥美拉唑静脉滴注。给药剂量均为每次40 mg,q12 h,疗程5 d,比较两组患者治疗前后血红蛋白值、显效时间、止血时间、临床疗效及不良反应等方面的差异。结果 两组患者治疗前后血红蛋白值、总有效率及不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的显效时间、止血时间显著低于对照组,差异有统计学意义(P<0.05)。结论 埃索美拉唑针剂用于治疗非静脉曲张性上消化道出血患者具有较好的临床疗效及安全性。
OBJECTIVE To observe the hemostatic effect and safety of esomeprazole injection in the treatment of non-variceal upper gastrointestinal bleeding. METHODS 138 patients with non-variceal upper gastrointestinal bleeding were randomly divided into experimental group(70 patients) and control group(68 patients). Both the two groups were treated with conventional therapy such as hemostasis,supplement blood capacity and stabilize the vital signs. On this basis,the experimental group were given esomeprazole intravenous therapy and the control group were given omeprazole intravenous therapy. The drug dosage of both the two groups was 40 mg,q12 h for 5 days. The changes of the Hb value,markedly effective time, hemostatic time,clinical efficacy and side effect were compared between the two groups before and after the treatment. RESULTS There was no significant difference in the changes of the Hb value,the total effect rate and the incidence rate of side effects between the two groups. The markedly effective time and hemostatic time of the experimental group was shorter than the control group dramatically,the differences were statistical significance (P<0.05). CONCLUSION Esomeprazole has better clinical efficacy and safety in the treatment of the non-variceal upper gastrointestinal bleeding patients.
基金项目:
作者简介:
杨丽芳,副主任药师,Tel:13553668859,E-mail:ylf99757@126.com
通讯作者:
参考文献:
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