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多索茶碱联合头孢他啶治疗老年结构性肺病并发社区获得性肺炎的药物经济学评价
作者:黄雅菲  俞平  徐碧云 
单位:南京市溧水区人民医院药剂科, 江苏 南京 211200
关键词:老年结构性肺病 社区获得性肺炎 头孢他啶 多索茶碱 药物经济学 
中图分类号:R956
文献标志码:
出版年,卷(期):页码:2020,30(1):51-54,
收稿日期:2019-8-12
摘要:
目的 对多索茶碱联合头孢他啶方案治疗老年结构性肺病并发社区获得性肺炎进行药物经济学评价。方法 前瞻性纳入100例老年结构性肺病患者资料,按药物治疗方案不同分为观察组和对照组,每组50例。观察组予以头孢他啶联合多索茶碱,对照组予以头孢他啶联合硫酸特布他林雾化液+吸入用布地奈德混悬液+吸入用异丙托溴铵溶液三联雾化吸入。所有患者均予吸氧、化痰等治疗。比较两组疗效、安全性及药物经济学指标。结果 有效性和安全性均无显著差异,故采用最小成本分析法,两组成本差异无统计学意义(P>0.05)。结论 多索茶碱联合头孢他啶方案治疗因特殊原因不能进行常规雾化吸入的老年结构性肺病并发社区获得性肺炎可达到理想的效果。
OBJECTIVE To evaluate the cost-effectiveness of doxofylline combined with ceftazidime in the treatment of elderly patient with structural lung disease complicated with community-acquired pneumonia. METHODS A total of 100 elderly patients with structural lung disease complicated with community-acquired pneumonia were randomly divided into observation group(n=50) and control group(n=50). Observation group received treatment of Ceftazidime combined with Doxofylline, while control group received treatment of Ceftazidime combined with triple atomization inhalation including terbutaline sulfate, budesonide, ipratropium bromide. All patients adopted oxygen inhalation and phlegm. The efficacy, safety and pharmacoeconomic in 2 groups were compared. RESULTS There was no significant difference in effectiveness and safety. Therefore, the economic evaluation was based on the least cost analysis method. Costs were comparable between the two groups (P>0.05). CONCLUSION Doxofylline combined with ceftazidime can achieve the desired effect in treating elderly patient with structural lung disease complicated with community-acquired pneumonia, who can't received conventional nebulized inhalation therapy due to special reasons.
基金项目:
常州四药医院药学科研基金项目(2018YX018)
作者简介:
黄雅菲,主管药师,研究方向:临床药学,Tel:13776523036,E-mail:bjf7715@126.com
通讯作者:
参考文献:
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