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基层医院鲍曼不动杆菌的耐药性分析与对策
作者:何杏仪 张旋华 何凤君 杨俊杰 
单位:佛山市顺德区中医院,广东 佛山528000
关键词:鲍曼不动杆菌 耐药性 抗菌药物 
中图分类号:R97
文献标志码:A
出版年,卷(期):页码:2010,20(1):46-48,
收稿日期:
摘要:
目的 分析本院鲍曼不动杆菌的感染及耐药情况,指导临床合理使用抗菌药物。方法 采用WHONET5·4对本院2009159株鲍曼不动杆菌药敏结果进行回顾性统计、分析。结果 鲍曼不动杆菌检出率最高的标本类型是痰,占84.3%,临床科室是ICU34.6%。在常用的抗菌药物中,亚胺培南的耐药率最低为34.6%,其次为阿米卡星54.1%,其它的β-内酰胺类抗菌药物耐药率均在57%以上。氨基糖苷类药物耐药率在50%~60%之间。左氧氟沙星的耐药率为54%,环丙沙星为58%结论 鲍曼不动杆菌耐药现象严重,临床应加强合理选用抗菌药物,减少耐药菌株的产生。

Objective To analyze the infection and drug resistance of acinetobacter baumanii (Ab) in Shunde District Hospital of Traditional Chinese Medicine, and to guide the rational application of antibiotic. Methods The results of drug-resistance test of 159 Ab in 2009 were retrospectively analyzed (WHONET5·4 was used for statistical analysis). Results Sputum specimen had the highest defective rate for Ab (84.3%). ICU had the highest defective rate in clinical departments (34.6%). Among the commonly used antibacterial drugs, imipenem had the lowest resistance rates (34.6%), followed by amikacin (54.1%), while the resistance rates of other β-lactam antimicrobial drugs were all 57%. Resistance rates of aminoglycoside were between 50%~60%. The resistance rate of levofloxacinI and ciprofloxacin was 54% and 58%, respectively. Conclusion The drug-resistant of acinetobacter baumannii is serious. Rational application of antibiotics should be strengthened to reduce the production of drug-resistant strains.

基金项目:
作者简介:
何杏仪,主管药师,Tel:13825552366,E鄄mail:hxy79@ tom. com
通讯作者:
参考文献:

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6 Stephane C, Nathalie C, Eric E, et al. AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains. J Antimicrob Chemother, 2003, 52(4): 629-635.

7 German B, Gonzalo C, Angeles MD, et al. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannli strain with a carbapenem hyd-rolyzing Enzyme:highlevel carbapenem resistance in A.baumanil is not due solely to the presence of β-lactamases. J Clin Microbiol, 2000, 38 (5): 3299-3305.

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9糜祖煌,黄支密,秦玲.鲍氏不动杆菌耐药性和氨基糖苷类修饰酶、β-内酰胺酶基因研究.中华医院感染学杂志,2004,14(9):968-971.
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